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作者:

Liu, Guang Jian (Liu, Guang Jian.) | Wang, Zheng Jun (Wang, Zheng Jun.) | Wang, Yun Fu (Wang, Yun Fu.) | Xu, Li Li (Xu, Li Li.) | Wang, Xiao Ling (Wang, Xiao Ling.) | Liu, Yong (Liu, Yong.) | Luo, Guo Jun (Luo, Guo Jun.) | He, Guo Hou (He, Guo Hou.) | Zeng, Yan Jun (Zeng, Yan Jun.)

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Scopus SCIE

摘要:

Cerebral vasospasm (CVS) is a frequent and unpredictable complication in patients with subarachnoid hemorrhage (SAH) and often leads to poor outcomes. This study was aimed at evaluating the efficacy and safety of fasudil in the treatment of CVS in patients with SAH. A search was conducted using the full-text database of Chinese scientific journals, the Wanfang Database (January 1999 to November 2010), the Chinese Medical Association Digital Journal Database, PubMed, the Cochrane library, OVID, and EMBase (searching through November 2010). A total of 8 studies met the inclusion criteria. The incidence rates of symptomatic CVS and CVS confirmed by angiography among the patients in the fasudil group were only 48% (odds ratio [OR] = 0.48, 95% confidence interval [CI]: 0.32-0.72, P = 0.0005) and 40% (OR = 0.40, 95% CI: 0.24-0-67, P = 0.0004) respectively of that of the control group. The odds ratios of cerebral infarction for all cases and cerebral infarction for CVS cases in the fasudil group were only 50% (OR = 0.50, 95% CI: 0.34-0.76, P = 0.0009) and 43% (OR = 0.43, 95% CI: 0.26-0.70, P = 0.0008) respectively of that of the control group. Fasudil greatly reduces the occurrence of CVS and cerebral infarction in SAH patients, significantly improves the clinical outcomes of the patients (as assessed by the Glasgow Outcome Scale). Because of the limited number of trials and samples available for analysis, the conclusions from the present study still need to be validated with results from large randomized, controlled clinical trials.

关键词:

Cerebral vasospasm Clinical outcome Fasudil Meta-analysis Subarachnoid hemorrhage

作者机构:

  • [ 1 ] [Liu, Guang Jian]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 2 ] [Wang, Yun Fu]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 3 ] [Xu, Li Li]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 4 ] [Wang, Xiao Ling]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 5 ] [Liu, Yong]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 6 ] [Luo, Guo Jun]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 7 ] [He, Guo Hou]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 8 ] [Zeng, Yan Jun]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 9 ] [Wang, Zheng Jun]Hubei Univ Med, Taihe Hosp Affiliated, Dept Pharm, Shiyan City 442000, Hubei Province, Peoples R China
  • [ 10 ] [Zeng, Yan Jun]Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022, Peoples R China

通讯作者信息:

  • [Liu, Guang Jian]Hubei Univ Med, Taihe Hosp Affiliated, Dept Neurol, 32 Renmin Rd, Shiyan City 442000, Hubei Province, Peoples R China

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来源 :

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

ISSN: 0031-6970

年份: 2012

期: 2

卷: 68

页码: 131-139

2 . 9 0 0

JCR@2022

ESI学科: PHARMACOLOGY & TOXICOLOGY;

ESI高被引阀值:174

JCR分区:2

中科院分区:3

被引次数:

WoS核心集被引频次: 51

SCOPUS被引频次: 64

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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