In　this　paper,　thermodynamic　optimization　is　applied　to　analyze　the　crystallization　process　of　the　gas　hydrate　related　to　the　gas　hydrate　cool　storage　system.　Thermodynamic　optimization　model　of　the　gas　hydrate　crystallization　process　is　established.　By　taking　the　entropy　generation　minimization　as　the　optimization　objective,　both　the　optimal　control　strategy　and　the　optimal　cooling　rate　of　the　gas　hydrate　crystallization　process　are　determined.　The　minimum　entropy　generation　corresponding　to　the　optimal　cooling　rate　decreases　by　7.8%　compared　with　normal　situation.　The　results　presented　in　this　paper　can　provide　important　guidelines　for　optimal　design　and　operation　of　the　gas　hydrate　crystallization　process.　Copyright　(C)　2010　John　Wiley　&　Sons,　Ltd.