In　the　process　of　HIV-1　virus　replication,　integrase　plays　a　quite　important　role.　Integrase　inhibitors　of　quinoline　ring　derivatives　were　analysed　by　the　Comparative　Molecular　Field　Analysis　(CoMFA),　Comparative　Molecular　Similarity　Induces　Analysis　(CoMSIA)　and　Topomer　CoMFA　methods.　Firstly,　77　compounds　were　selected　to　form　the　training　and　test　sets.　Secondly,　predictive　models　were　constructed　with　the　CoMFA,　CoMSIA　and　Topomer　CoMFA　methods.　The　CoMFA　model　yielded　the　best　model　with　q(2)　of　0.76　and　r(training)(2)　of　0.99,　the　CoMSIA　model　has　q(2)　=　0.70　and　r(training)(2)　of　0.99,　while　the　Topomer　CoMFA　model　has　q(2)　of　0.66　and　r(training)(2)　of　0.97.　These　results　provide　a　helpful　contribution　to　the　design　of　novel　highly　active　HIV-1　integrase　inhibitors.