Two　kinds　of　amino　groups　were　employed　to　functionalize　bimodal　mesoporous　silicas　and　related　drug　carriers　were　prepared.　The　characterization　results　of　XRD,　N-2　adsorption　and　desorption,　FT-IR　and　TG　all　confirmed　the　structural　integrity　of　the　bimodal　mesopore　architecture　after　introduction　treatment　of　functional　groups　and　the　successful　adsorption　of　aspirin.　In　order　to　investigate　the　interaction　among　the　mesoporous　structure,　the　functional　groups　grafted　onto　the　mesoporous　surface　and　the　existential　microenvironment　of　the　drug　molecules　inside　the　mesoporous　channels,　the　thermal　decomposition　behaviors　of　amino　groups　modified　and　aspirin　loaded　carriers　were　studied　based　on　the　thermogravimetric　analysis　in　details.　According　to　the　thermogravimetry　and　derivative　thermogravimetry　results,　the　apparent　activation　energies　E-a　of　thermal　decomposition　for　all　related　samples　have　been　evaluated　by　Kissinger　and　Flynn-Wall-Ozawa　methods.　Meanwhile,　their　thermal　decomposition　mechanisms　have　been　suggested　by　using　Coats　and　Redfern　methods.　All　these　featured　consequence　could　provide　a　deeper　understanding　for　large　loading　capacity　and　controlled　release　of　drug-carriers　in　the　pharmaceutical　application.