Studies　showed　that　vascular　diseases　were　prone　to　occur　in　curved　arteries.　In　this　paper,　biomechanical　behaviors　of　curved　artery　with　flexible　wall　subjected　to　physiological　flow　were　presented.　Fluid-structure　interaction　effect　was　considered.　The　Von　Mises　stress　variation　and　distribution　patterns,　the　influence　of　artery　curvature　and　flexibility　on　peak　wall　Von　Mises　stress,　diameter　change　and　cross　sectional　shape　variation　of　the　curved　artery　in　the　cardiac　cycle　were　studied　in　detail.　We　believe　that　the　findings　may　provide　important　implications　for　individualized　treatment　for　patients　with　cardiovascular　disease.　(C)　2011　Elsevier　Ltd.　All　rights　reserved.