A　novel　poly(l-aspartic)　derivative　(PAL-DPPE)　containing　polylactide　and　1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine　(DPPE)　segments　has　been　successfully　synthesized.　The　chemical　structures　of　the　copolymers　were　confirmed　by　Fourier-transform　infrared　spectroscopy　(FTIR),　NMR　((1)H　NMR,　(13)C　NMR,　(31)P　NMR),　and　thermogravimetric　analysis　(TGA).　Fluorescence　spectroscopy,　dynamic　light　scattering　(DLS),　and　transmission　electron　microscopy　(TEM)　confirmed　the　formation　of　micelles　of　the　PAL-DPPE　copolymers.　In　order　to　estimate　the　feasibility　as　novel　drug　carriers,　an　anti-tumor　model　drug　doxorubicin　(DOX)　was　incorporated　into　polymeric　micelles　by　double　emulsion　and　nanoprecipitation　method.　The　DOX-loaded　micelle　size,　size　distribution,　and　encapsulation　efficiency　(EE)　were　influenced　by　the　feed　weight　ratio　of　the　copolymer　to　DOX.　In　addition,　in　vitro　release　experiments　of　the　DOX-loaded　PAL-DPPE　micelles　exhibited　that　faster　release　in　pH　5.0　than　their　release　in　pH　7.4　buffer.　The　poly(l-aspartic)　derivative　copolymer　was　proved　to　be　an　available　carrier　for　the　preparation　of　micelles　for　anti-tumor　drug　delivery.