The　aim　of　our　study　was　to　validate　the　effect　of　radionuclide　imaging　in　early　monitoring　of　the　bone＇s　reconstruction,　the　animal　model　of　bone　defect　was　made　on　the　rabbits　repaired　with　HA　artificial　bone.　The　ability　of　bone　defect　repair　was　evaluated　by　using　radionuclide　bone　imaging　at　2,　4,　8　and　12　weeks　postoperatively.　The　results　indicate　that　the　experimental　group　stimulated　more　bone　formation　than　that　of　the　control　group.　The　differences　of　the　bone　reconstruction　ability　were　statistically　significant　(p＜0.05).　The　nano-HA　artificial　has　good　bone　conduction,　and　it　can　be　used　for　the　treatment　of　bone　defects.　Radionuclide　imaging　may　be　an　effective　and　first　choice　method　for　the　early　monitoring　of　the　bone＇s　reconstruction.　(C)　2011　Association　of　Basic　Medical　Sciences　of　FBI　H.　All　rights　reserved