Protein　protein　docking　has　made　much　progress　in　recent　years,　but　challenges　still　exist.　Here　we　present　the　application　of　our　docking　approach　Ho　Dock　in　CAPRI.　In　this　approach,　a　binding　site　prediction　is　implemented　to　reduce　docking　sampling　space　and　filter　out　unreasonable　docked　structures,　and　a　network-based　enhanced　combinatorial　scoring　function　HPNCscore　is　used　to　evaluate　the　decoys.　The　experimental　information　was　combined　with　the　predicted　binding　site　to　pick　out　the　most　likely　key　binding　site　residues.　We　applied　the　Ho　Dock　method　in　the　recent　rounds　of　the　CAPRI　experiments,　and　got　good　results　as　predictors　on　targets　39,　40,　and　41.　We　also　got　good　results　as　scorers　on　targets　35,　37,　40,　and　41.　This　indicates　that　our　docking　approach　can　contribute　to　the　progress　of　protein　protein　docking　methods　and　to　the　understanding　of　the　mechanism　of　protein　protein　interactions.　Proteins　2010;　78:3150-3155.　(C)　2010　Wiley-Liss,　Inc.