A　series　of　chiral　C-2-symmetrical　macrocycles　containing　two　alpha-amino　acids　and　two　biaryl　subunits　have　been　designed　and　synthesized　in　moderate　yields　(36-53%).　The　absolute　configurations　of　biaryl　motifs　in　these　chiral　macrocycles　were　established　by　X-ray　crystal　structure　analysis　and　CD　measurements.