In　this　paper,　the　influences　of　water　rinsing　conditions　on　the　cumulative　membrane　permeate　filtrate　volume　(CMPFV)　were　systematically　investigated　by　a　combination　of　orthogonal　table　and　multivariate　linear　regression　methods.　The　experiments　were　performed　with　a　feed　suspension　from　an　SBR　and　deionized　water　in　a　laboratory-scale　dead-end　microfiltration　test　unit　with　a　0.1　mu　m　polyethersulfone　(PES)　microfiltration　membrane　respectively.　The　results　showed　that　the　resistance　due　to　cake　filtration　dominated　the　flux　decline　under　the　conditions　studied.　Water　rinsing　process　can　restore　the　declined　flux　nearly　to　its　initial　value,　but　its　ability　is　gradually　reducing　with　the　increase　of　the　cleaning　cycle,　which　is　associated　with　the　increasing　accumulation　of　irreversible　pollutants　onto　and　into　the　membrane　pores.　The　average　contribution　of　water　rinsing　conditions　on　CMPFV　were　relative　flux　(38.3%)＞　detergent　temperature　(21.6%)＞　washing　times　(19.3%)＞　agitation　speed　(11.2%)＞detergent　volume　(9.6%).　Here,　except　for　the　relative　flux,　the　others　factors,　such　as　detergent　temperature,　washing　times,　agitation　speed　and　detergent　volume　had　a　positive　contribution　to　CMPFV.　In　addition,　the　relationship　between　water　rinsing　conditions　and　CMPFV　was　analyzed　and　defined　quantitatively　for　4　cycles　respectively　and　it　can　give　good　predictive　results.　(C)　2010　Elsevier　B.V.　All　rights　reserved.