This　work　evaluates　the　protective　effects　of　Chinese　herbs　against　ONOO--induced　biomolecule　damage.　Thirty-two　Chinese　traditional　herbs　were　preliminarily　screened　for　their　ONOO--scavenging　activity　by　the　fluorometric　method.　The　potency　of　scavenging　activity　was　in　the　following　order:　Apis　cerana　Fabricius　(Propolis)　＞　Rosmarinus　officinalis　L　(Rosemary)　＞　Pseudolarix　amabilis　(Nelson)　Rehd.　(Pine　Bark　PE)　＞　Echinacea　Moenck.　(Echinacea);　the　remaining　twenty-eight　herbs　performed　unsatisfactorily　for　their　scavenging　activity.　The　four　extracts　with　high　ONOO-　scavenging　activity　were　selected　for　further　characterization　of　their　inhibiting　effects　on　DNA　single　breaks,　tyrosine　nitration　and　LDL　oxidation.　A　further　study　of　the　origin　of　this　scavenging　activity　on　the　major　active　components　showed　cichoric　acid　and　rosemary　acid　to　both　have　strong　ability　to　scavenge　ONOO-.　These　scavengers　might　be　developed　as　therapeutic　drugs　for　preventing　ONOO--involved　diseases.