Fe-doped　TiO2,　microspheres　with　hollow　interiors　were　prepared　using　polystyrene　latex　particles　as　the　template　and　peroxo-titanium　complex　as　the　precursor.　The　resulting　samples　are　characterized　by　XRD,　SEM,　TEM,　XPS　and　UV-Vis.　The　results　reveal　that　the　Fe-doped　TiO2　hollow　microspheres　show　pure　anatase　phase　and　have　a　good　hollow　structure.　When　adding　a　concentration　of　Fe　into　the　system,　the　electronic　structures　changed　and　obviously　enhance　the　absorption　in　the　visible　light　region.　TiO2　hollow　microspheres　with　0.75%　Fe　dosage　exhibited　the　superior　photocatalytic　activity　for　the　decomposition　of　methylene　blue　under　visible-light　irradiation.　The　possible　photocatalytic　mechanism　is　proposed.