Fluorite-type　nanosized　Ce0.60Zr0.35Y0.05O2　(nano-CZY)　solid　solution　catalysts　that　are　relatively　uniform　in　particle　size　(4-5　nm)　and　y　CrOx/nano-CZY　(y　is　the　weight　percentage　of　Cr2O3　ranging　from　2　to　10　wt%)　catalysts　were　prepared　by　the　ethylene　glycol-assisted　CTAB-templated　co-precipitation　and　incipient　wetness　impregnation　methods,　respectively.　The　materials　were　characterized　by　a　number　of　analytical　techniques　and　their　catalytic　performance　was　evaluated　for　the　oxidative　dehydrogenation　of　isobutane.　The　y　CrOx/nano-CZY　catalysts　show　excellent　activities,　with　the　y　=　8　wt%　one　performing　the　best　(ca.　93%　isobutene　selectivity　and　ca.　10%　isobutene　yield　at　540　degrees　C　and　30,000　mL/(g(cat)　h)).　We　conclude　that　the　good　reducibility　of　the　highly　dispersed　CrOx　domains　and　the　promotion　of　O-2　adsorption　at　oxygen　vacancies　of　nano-CZY　(for　enhanced　oxidation　of　the　reduced　catalyst)　are　responsible　for　the　excellent　performance　of　the　8　wt%　CrOx/nano-CZY　catalyst.　(C)　2010　Elsevier　B.V.　All　rights　reserved.