Styrylquinoline　derivatives　are　demonstrated　to　be　HIV-1　integrase　inhibitors.　On　the　basis　of　our　previous　CoMFA　analysis　of　a　series　of　styrylquinoline　derivatives,　N[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide　derivatives　were　designed　and　synthesized,　and　their　possible　HIV　IN　inhibitory　activity　was　evaluated.