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作者:

Zhu, W. (Zhu, W..) | Zhang, X. (Zhang, X..) | Wang, D. (Wang, D..) | Lu, W. (Lu, W..) | Ou, Y. (Ou, Y..) | Han, Y. (Han, Y..) | Zhou, K. (Zhou, K..) | Liu, H. (Liu, H..) | Fen, W. (Fen, W..) | Peng, L. (Peng, L..) | He, C. (He, C..) | Zeng, Y. (Zeng, Y..)

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EI Scopus SCIE

摘要:

This study evaluates the osteoconductive property of nano-hydroxyapatite (nano-HA) material and the potential application of nano-HA as artificial bone in repairing bone defects, and tries to analyse the scientific explanation of these. The animal model of bone defects is made on the bilateral radius of 39 New Zealand white rabbits, which are divided into an experimental group (the bone defect is repaired with nano-HA artificial bone), a control group (the bone defect is repaired with HA artificial bone) and a blank group (the defect is empty) randomly. The bone conduction function of different materials is evaluated by gross observation, alkaline phosphatase (ALP) detection in serum, histopathological study, X-ray examination, scanning electron microscopy (SEM) and biomechanical analysis at the 4th, 8th and 12th week postoperatively. The experimental group is found to stimulate more bony callus than the control and blank groups. These differences in bone conduction function are statistically significant (P < 0.05). In conclusion, nano-HA artificial bone can be potentially applied to the treatment of bone defects.

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作者机构:

  • [ 1 ] [Zhu, W.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 2 ] [Wang, D.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 3 ] [Lu, W.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 4 ] [Ou, Y.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 5 ] [Han, Y.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 6 ] [Zhou, K.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 7 ] [Liu, H.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 8 ] [Fen, W.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 9 ] [Peng, L.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 10 ] [He, C.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China
  • [ 11 ] [Zhang, X.]Beijing Univ Technol, Beijing 100022, Peoples R China
  • [ 12 ] [Zeng, Y.]Beijing Univ Technol, Beijing 100022, Peoples R China

通讯作者信息:

  • [Zhu, W.]Shenzhen Second Peoples Hosp, Dept Traumat Orthopaed, Shenzhen 518035, Peoples R China

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来源 :

MICRO & NANO LETTERS

年份: 2010

期: 1

卷: 5

页码: 19-27

1 . 3 0 0

JCR@2022

ESI学科: PHYSICS;

JCR分区:3

中科院分区:4

被引次数:

WoS核心集被引频次: 32

SCOPUS被引频次: 35

ESI高被引论文在榜: 0 展开所有

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