Based　on　the　structure　of　the　integrase　core　domain　and　pharmacophore　perception,　the　authors　picked　out　the　hit　quinolone　derivative　I　as　the　lead　compound　via　virtual　screen　in　ACD,　MDDR,　NO　and　Chinese　Herb　three-dimensional　database　with　the　aid　of　DOCK4.0　program　and　synthesized　a　series　of　analogues　of　compound　1.　Their　primary　anti-HIV　properties　against　integrase　reveal　that　6-position　methyl　group　on　the　benzene　ring　of　quinolone　plays　a　more　important　role　than　chlorine,　7-position　methyl　group　or　no　substituted　group.　But　the　title　compounds　exhibit　little　difference　when　the　substituted　group　was　phenyl　or　thienyl　on　the　pyridine　ring　of　quinoline.