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Author:

Wu, Zhe Bao (Wu, Zhe Bao.) | Li, Chu Zhong (Li, Chu Zhong.) | Zong, Xu Yi (Zong, Xu Yi.) | Su, Zhi Peng (Su, Zhi Peng.) | Zeng, Yan Jun (Zeng, Yan Jun.) | Zhang, Ya Zhuo (Zhang, Ya Zhuo.)

Indexed by:

Scopus SCIE

Abstract:

Objective Estradiol (E2) acts to modulate the ratio of two dopamine D2 receptor isoforms (D2L/D2S) by the nuclear estrogen receptor (ER) and to reduce dopamine's inhibitory action on PRL secretion. Here we demonstrate the correlation between the expression of ER mRNA and D2R mRNA isoforms in pituitary neoplasms cells. Methods Twenty-four human pituitary adenomas (14 prolactinomas and 10 gonadotrope tumors) were examined for the expression of both ER mRNA and D2R mRNA by means of semi-quantitative RT-PCR analysis. Results No significant difference was found in ER beta mRNA expression levels between prolactinomas and gonadotrope tumors (P = 0.871), but there was a significant difference in the expression of ER alpha mRNA (P = 0.003). The significant difference was found between the two pituitary adenomas types in both levels of D2S and D2L mRNA expression (P = 0.036 and 0.007 respectively). Furthermore, both levels of expression in prolactinomas were significantly higher than that in gonadotrope tumors. Additionally, a negative correlation between D2S and ER alpha mRNA expression and a positive correlation between D2L and ER alpha mRNA expression were found in these tumors. Conclusion This study for the first time shows a good correlation between expression of ER and D2R isoforms in prolactinomas and gonadotrope tumors. Reducing the amount of the ER alpha in neoplasm cells can alter the ratio of D2L/D2S, which may increase the drug sensitivity of pituitary adenomas.

Keyword:

Gonadotrope adenoma Prolactinoma Dopamine 2 receptor isoforms Estrogen receptor isoforms

Author Community:

  • [ 1 ] [Wu, Zhe Bao]Capital Univ Med Sci, Dept Neurosurg, Beijing Neurosurg Inst, Beijing 100050, Peoples R China
  • [ 2 ] [Li, Chu Zhong]Capital Univ Med Sci, Dept Neurosurg, Beijing Neurosurg Inst, Beijing 100050, Peoples R China
  • [ 3 ] [Zong, Xu Yi]Capital Univ Med Sci, Dept Neurosurg, Beijing Neurosurg Inst, Beijing 100050, Peoples R China
  • [ 4 ] [Zhang, Ya Zhuo]Capital Univ Med Sci, Dept Neurosurg, Beijing Neurosurg Inst, Beijing 100050, Peoples R China
  • [ 5 ] [Wu, Zhe Bao]Wenzhou Med Coll, Affiliated Hosp 1, Dept Neurosurg, Wenzhou 325000, Peoples R China
  • [ 6 ] [Su, Zhi Peng]Wenzhou Med Coll, Affiliated Hosp 1, Dept Neurosurg, Wenzhou 325000, Peoples R China
  • [ 7 ] [Zeng, Yan Jun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China

Reprint Author's Address:

  • [Zhang, Ya Zhuo]Capital Univ Med Sci, Dept Neurosurg, Beijing Neurosurg Inst, Beijing 100050, Peoples R China

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Source :

JOURNAL OF NEURO-ONCOLOGY

ISSN: 0167-594X

Year: 2009

Issue: 1

Volume: 94

Page: 135-139

3 . 9 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

JCR Journal Grade:2

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 5

SCOPUS Cited Count: 5

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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