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作者:

Yang YanHui (Yang YanHui.) | Liang PeiPeng (Liang PeiPeng.) | Lu ShengFu (Lu ShengFu.) | Li KunCheng (Li KunCheng.) | Zhong Ning (Zhong Ning.)

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Scopus SCIE

摘要:

Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal agings, and whether the activation pattern of this region was different between MCI patients and normal agings. The fMRI results indicated that MCI patients had no difference from normal agings in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal agings, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal agings. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of agings, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.

关键词:

mild cognitive impairment inductive reasoning functional MRI

作者机构:

  • [ 1 ] [Yang YanHui]Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China
  • [ 2 ] [Li KunCheng]Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China
  • [ 3 ] [Liang PeiPeng]Beijing Univ Technol, Int WIC Inst, Beijing 100124, Peoples R China
  • [ 4 ] [Lu ShengFu]Beijing Univ Technol, Int WIC Inst, Beijing 100124, Peoples R China
  • [ 5 ] [Zhong Ning]Beijing Univ Technol, Int WIC Inst, Beijing 100124, Peoples R China
  • [ 6 ] [Yang YanHui]Beijing Municipal Lab Brain Informat, Beijing 100124, Peoples R China
  • [ 7 ] [Liang PeiPeng]Beijing Municipal Lab Brain Informat, Beijing 100124, Peoples R China
  • [ 8 ] [Lu ShengFu]Beijing Municipal Lab Brain Informat, Beijing 100124, Peoples R China
  • [ 9 ] [Li KunCheng]Beijing Municipal Lab Brain Informat, Beijing 100124, Peoples R China
  • [ 10 ] [Zhong Ning]Beijing Municipal Lab Brain Informat, Beijing 100124, Peoples R China
  • [ 11 ] [Zhong Ning]Maebashi Inst Technol, Dept Life Sci & Informat, Maebashi, Gunma 3710816, Japan

通讯作者信息:

  • [Li KunCheng]Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China

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来源 :

SCIENCE IN CHINA SERIES C-LIFE SCIENCES

ISSN: 1006-9305

年份: 2009

期: 8

卷: 52

页码: 789-795

JCR分区:3

中科院分区:1

被引次数:

WoS核心集被引频次: 39

SCOPUS被引频次: 41

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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