收录:
摘要:
A novel approach to synthesize chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate was developed. Chitosan-d4T monophosphate prodrug with a phosphoramidate linkage was efficiently synthesized through Atherton-Todd reaction. In vitro drug release studies in pH 1.1 and 7.4 indicated that chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate prefers to release the d4T 5'-(O-isopropyl) monophosphate than free d4T for a prolonged period. The results suggested that chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate may be used as a sustained polymeric prodrug for improving therapy efficacy and reducing side effects in antiretroviral treatment. (C) 2009 Elsevier Ltd. All rights reserved.
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通讯作者信息:
来源 :
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN: 0960-894X
年份: 2009
期: 9
卷: 19
页码: 2566-2569
2 . 7 0 0
JCR@2022
ESI学科: CHEMISTRY;
JCR分区:2
中科院分区:1