Pigs　are　currently　considered　the　most　likely　source　of　organs　for　human　xenotransplantation　because　of　anatomical　and　physiological　similarities　to　humans,　and　the　relative　ease　to　be　bred　in　large　numbers.　Along　with　the　fast　development　of　the　genetic　engineering　and　organ　transplant　immunity　medical　science,　the　research　of　liver　xenotransplantation　suffers　the　very　big　valuing　in　recent　years.　Whether　the　livers　from　different　species　after　transplanting　can　perform　the　normal　function,　depends　on　the　function　regeneration　and　lucid　rates　of　hepatic　portal　vein.　The　objective　of　this　study　was　to　investigate　the　age　effect　on　biomechanical　properties　of　pig　hepatic　portal　vein　to　pave　the　way　for　seeking　a　reliable　biomaterial　for　future　pig-to-human　liver　xenotransplantation.　The　biomechanical　remodelling　of　the　hepatic　portal　vein　of　pigs　for　1,2,3,4,5　and　6　months　(n　=　6　per　month)　were　measured　in　this　study.　The　blood　vessel　was　given　periodic　permanent　loading　and　unloading,　and　repeated　force-deformation　data　were　obtained.　The　incremental　modulus　(Einc),　the　longitudinal　incremental　modulus　(Ep),　the　circumferential　incremental　modulus　(Ev),　incremental　compliance　(C)　and　wall　thickness　were　calculated　based　on　the　recorded　pressure-diameter　curves　from　experimental　data.　The　incremental　modulus,　pressure　strain　modulus　and　the　volume　modulus　of　the　pig　hepatic　portal　vein　increases　with　the　age　increased　(P　＜　0.01),　while　the　compliance　decreased　with　the　increasing　of　the　age　(P　＜　0.01).　Our　present　study　suggests　that　the　biomechanical　properties　of　the　pig　hepatic　portal　vein　are　age　dependent,　the　pig　hepatic　portal　vein　with　biomechanical　properties　that　match　those　of　human　hepatic　portal　vein　should　be　chosen　for　liver　xenotransplantation.