摘要:
Polycyclic aromatic hydrocarbons (PAHs),which constitute a major class of environmental pollu tants are posing a threat to human health. Benzopyrene,an index of PAH levels omnipresent in the everyday environment ,becomes toxic only when being metabolically and/or photo-activated,i. e. ,in the pres ence of UV light. Free radicals such as superoxide anions (''O2),hydrogen peroxide (H2O2),hydroxyl radicals (''OH) and singlet oxygen (1O2) are involved in carcinogenesis. Wei CE etc[1] studied the effects of different scavengers of active oxygen species (superoxide dismutase,catalase,mannitol and dimethyfu ran) on promoting B[a]P mutagenicity. Bryla P ete[2] investigated the roles of several ROS scavengers in the oxidation and binding of B[a]P to calf thymus DNA using the 32p-postlabeling assay.
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