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作者:

Qiao, A (Qiao, A.) | Liu, YJ (Liu, YJ.) (学者:刘有军) | Li, SY (Li, SY.) | Zhao, H (Zhao, H.)

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摘要:

The Coronary Artery Bypass Graft (CABG) yields excellent results and remains the modern standard of care for treatment of occlusive disease in the cardiovascular system. However, the development of anastomotic Intimal Hyperplasia (IH) and restenosis can compromise the medium-and-long term effects of the CABG. This problem can be correlated with the geometric configuration and hemodynamics of the bypass graft. A novel geometric configuration was proposed for the CABG with two symmetrically implanted grafts for the purpose of improving the hemodynamics. Physiological blood flows in two models of bypass grafts were simulated using numerical methods. One model was for the conventional bypass configuration with a single graft (1-way model); the other model was for the proposed bypass configuration with two grafts (2-way model). The temporal and spatial distributions of hemodynamics, such as flow patterns and Wall Shear Stress (WSS) in the vicinity of the distal anastomoses, were analyzed and compared. Calculation results showed that the 2-way model possessed favorable hemodynamics with uniform longitudinal flow patterns and WSS distributions, which could decrease the probability of restenosis and improve the effect of the surgical treatment. Concerning the limitations of the 2-way bypass grafts, it is necessary to perform animal experiments to verify the viability of this novel idea for the CABG.

关键词:

anastomosis CABG cardiovascular system geometric configuration hemodynamics intimal hyperplasia restenosis

作者机构:

  • [ 1 ] Beijing Univ Technol, Beijing 100022, Peoples R China
  • [ 2 ] 202 Hosp, Liaoning 110003, Peoples R China
  • [ 3 ] Shantou Univ, Coll Med, Guangdong 515031, Peoples R China

通讯作者信息:

  • [Qiao, A]Beijing Univ Technol, Beijing 100022, Peoples R China

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来源 :

JOURNAL OF BIOLOGICAL PHYSICS

ISSN: 0092-0606

年份: 2005

期: 2

卷: 31

页码: 161-182

1 . 8 0 0

JCR@2022

ESI学科: BIOLOGY & BIOCHEMISTRY;

JCR分区:4

被引次数:

WoS核心集被引频次: 12

SCOPUS被引频次: 19

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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