The　rapid　development　of　computer　modeling　in　recent　years　offers　opportunities　for　materials　preparation　in　a　more　economic　and　efficient　way.　In　the　present　paper,　a　practicable　route　for　research　and　development　of　advanced　materials　by　applying　the　visual　and　quantitative　modeling　technique　on　the　mesoscale　is　introduced.　A　3D　simulation　model　is　developed　to　describe　the　microstructure　evolution　during　the　whole　process　of　deformation,　recrystallization　and　grain　growth　in　a　material　containing　particles.　In　the　light　of　simulation　optimization,　the　long-term　stabilized　fine　grain　structures　ideal　for　high-temperature　applications　are　designed　and　produced.　In　addition,　the　feasibility,　reliability　and　prospects　of　material　development　based　on　mesoscale　modeling　are　discussed.