The　paper　described　a　limited　part　of　the　coagulation　pathway,　and　in　particular　the　inhibitory　effects　of　activated　protein　C　in　the　context　of　thrombin　production.　This　is　a　computational　modeling　study　with　various　assumption　made　of　kinetic　rates　laws　and　their　summation.　The　level　of　complexity　and　assumed　parameters　makes　conclusions　uncertain.　However,　an　interesting　outcome　is　that　kinetic　reaction　rates　may　show　oscillation　behavior　under　particular,　high　levels　of　protein　C　feedback　inhibition.　The　model　would　defy　quantitative　practical　use,　but　could　have　predictive　value　as　a　qualitative　descriptor　of　coagulation.　(C)　2004　IPEM.　Published　by　Elsevier　Ltd.　All　rights　reserved.