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Author:

Lu, BZ (Lu, BZ.) | Wang, BH (Wang, BH.) | Chen, WZ (Chen, WZ.) | Wang, CX (Wang, CX.)

Indexed by:

Scopus SCIE PubMed

Abstract:

An effective and fast minimization approach is proposed for the prediction of protein folding, in which the 'relative entropy' is used as a minimization function and the off- lattice model is used. In this approach, we only use the information of distances between the consecutive C-alpha atoms along the peptide chain and a generalized form of the contact potential for 20 types of amino acids. Tests of the algorithm are performed on the real proteins. The root mean square deviations of the structures of eight folded target proteins versus the native structures are in a reasonable range. In principle, this method is an improvement on the energy minimization approach.

Keyword:

minimization relative entropy protein folding prediction off-lattice model

Author Community:

  • [ 1 ] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100022, Peoples R China
  • [ 2 ] Univ Sci & Technol China, Dept Astron & Appl Phys, Hefei 230026, Peoples R China
  • [ 3 ] Acad Sinica, Inst Biophys, Beijing 100101, Peoples R China

Reprint Author's Address:

  • [Wang, CX]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100022, Peoples R China

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Source :

PROTEIN ENGINEERING

ISSN: 0269-2139

Year: 2003

Issue: 9

Volume: 16

Page: 659-663

JCR Journal Grade:2

Cited Count:

WoS CC Cited Count: 9

SCOPUS Cited Count: 8

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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