As　most　residents　spend　more　than　90%　of　their　time　in　buildings,　acceptable　and　reasonable　control　of　both　indoor　thermal　comfort　and　air　quality　is　imperative　to　ensure　occupants＇　health　status　and　work　productivity.　However,　current　control　strategies　generally　take　either　thermal　comfort　or　indoor　air　quality　as　a　single　loop,　rather　than　the　concurrent　control　of　two.　To　analyze　their　mutual　influence,　this　study　investigated　the　performance　of　three　multi-control　approaches,　i.e.,　proportional　integral　derivative　(PID)　control　of　thermal　comfort　and　a　fixed　outdoor　air　ratio,　PID　control　of　thermal　comfort　and　design　outdoor　air　rate,　and　PID　control　of　thermal　comfort　and　occupancy-based　demand-controlled　ventilation.　As　a　pilot　study,　three　typical　control　methods　were　implemented　to　a　multi-zone　building　via　OpenModelica　modeling.　The　results　indicate　that　indoor　air　temperature　can　be　well-maintained　under　three　control　methods,　however,　the　CO(2)concentration　under　the　fixed　outdoor　air　ratio　was　over　1000　ppm,　leading　to　poor　indoor　air　quality.　The　control　strategy　with　the　design　outdoor　air　rate　could　not　properly　ensure　the　CO(2)concentration,　due　to　the　over-ventilated　or　under-ventilated　phenomena,　subsequently　resulting　in　unnecessary　energy　waste.　The　occupancy-based　demand　controlled　ventilation　could　maintain　the　CO(2)concentration　under　the　set-point　with　an　intermediate　power　energy　utilization.