The　influence　analysis　of　the　site　condition　is　a　key　issue　considered　in　the　seismic　design　of　nuclear　power　engineering　on　non-rock　sites.　To　study　the　soil-structure　interaction　(SSI)　effect　of　the　site　conditions　on　the　structural　seismic　response　of　nuclear　power　engineering,　we　used　a　CAP1400　nuclear　power　plant　as　a　case　study　subject　and　performed　a　shake　table　testing　of　a　soil-structure　system　model.　The　test　results　indicate　that　there　are　strong　nonlinear　effects　of　non-rock　site,　that　is,　with　increase　of　seismic　input　level　(peak　ground　acceleration,　PGA),　the　natural　vibration　frequency　of　the　soil-structure　system　decreased　significantly,　and　the　damping　ratio　increased;　Under　all　seismic　input　levels,　the　site　amplification　phenomena　occurred　in　different　directions,　and　the　response　accelerations　of　soil　and　structure　in　the　high-frequency　range　(＞3　Hz)　are　greatly　influenced　by　the　SSI　effect;　The　cracks　began　to　appear　in　the　model　soil　under　lower　seismic　input　level　(PGA　0.20　g)　and　developed,　lengthen　and　widen　under　the　high　seismic　input　level　(PGA＞0.30　g),　and　the　soil　cracks　were　almost　all　connected　under　the　SME　seismic　input　level　(PGA　0.51　g),　but　still　no　micro-cracks　were　detected　on　the　model　structure;　Under　the　SSE　seismic　input　level　(PGA　＞=　0.30　g)　the　contact　surface　separation　appeared　on　the　contact　surfaces　of　the　model　soil　and　the　structure　foundation,　and　then　under　the　ultra　SME　seismic　input　level　(PGA　0.84　g)　the　structure　foundation　became　unbalanced　so　that　the　soil-structure　system　failed.　The　influence　of　the　site　conditions　on　the　seismic　response　of　the　structure　was　significant.　The　seismic　response　analysis　and　seismic　design　of　the　nuclear　island　structure　on　no-rock　sites　should　take　into　account　the　effects　of　site　conditions　and　soil-structure　interaction.