It　is　worth　to　reveal　the　long-term　responses　of　antibiotic　resistance　genes　(ARGs)　in　aerobic　granular　sludge　(AGS)　system　exposed　to　high　level　enrofloxacin　(ENR),　sulfadiazine　(SDZ)　and　triclosan　(TCS).　In　present　study,　ppm　level　ENR,　SDZ　and　TCS　were　added　into　three　AGS　reactors,　respectively.　ARGs　in　ENR　and　SDZ　systems　showed　trends　of　increasing　first　and　then　decreasing,　which　were　contrary　to　that　in　TCS　system.　80%,　56%　and　40%　ARGs　in　ENR,　SDZ　and　TCS　systems,　respectively,　were　enriched　after　loading,　but　several　ARGs　still　kept　high　enrichment　values　after　the　withdrawn　of　loadings.　The　dominant　bacteria　in　ENR　(Flavobacterium),　SDZ　(Candidatus_Competibacter　and　Defluviicoccus)　and　TCS　(Defluviicoccus)　systems　might　contribute　to　the　reductions　of　ARGs.　IntI1　altered　the　overall　ARGs　profiles　through　horizontal　gene　transfer.　The　interactions　of　bacterial　communities　and　environmental　factors　might　be　responsible　for　the　different　ARGs　patterns　in　ENR,　SDZ　and　TCS　systems.