Advance　guide　signs　for　exit　ramps　along　urban　expressways　are　increasingly　critical,　enhancing　safety　and　mobility　by　improving　the　flow　of　vehicles　exiting　urban　expressways.　However,　research　has　devoted　scant　attention　to　advance　guide　signs　for　exit　ramps.　This　study　aimed　to　identify　and　propose　optimal　design　alternatives　for　exit　ramp　advance　guide　signs　for　different　types　of　exit　spacing.　This　study　conducted　a　driving　simulation　experiment　consisting　of　five　design　alternatives　of　advance　guide　signs　and　two　exit　ramp　spacing　variation.　Eight　indicators　were　measured.　The　repeated-measure　analysis　of　variances　(ANOVA)　and　the　Technique　for　Order　of　Preference　by　Similarity　to　Ideal　Solution　(TOPSIS)　were　performed　for　the　influence　analysis　and　efficiency　evaluation　of　different　schemes.　Influence　analysis　results　showed　better　design　alternatives　in　five　schemes　of　advance　guide　signs,　enabling　drivers　to　more　easily　locate　destination　exits　and　change　lanes　fewer　times,　in　addition　to　reducing　drivers＇　need　to　decelerate,　and　improving　traffic　flow　in　the　key　influence　range　of　destination　exit　ramps.　The　percentage　of　drivers　successfully　locating　the　destination　exits　also　increased　with　optimal　design　alternatives　of　advance　guide　signs.　When　the　exit　ramp　spacing　tightened,　on　the　other　hand,　drivers　had　to　make　more　lane　changes　and　accelerate　and　decelerate　more　frequently　in　the　key　influence　range.　As　a　result,　a　lower　percentage　of　drivers　successfully　located　destination　exits.　Efficiency　evaluation　results　were　also　obtained.　In　tight　spacing,　three　advance　guide　signs　are　recommended　to　be　placed　at　1　km,　0.5　km　and　0　km　prior　to　the　beginning　of　the　tapered　deceleration　lane.　If　conditions　are　limited,　at　least　two　advance　guide　signs　should　be　used.　With　greater　spacing,　four　advance　guide　signs　are　recommended,　located　at　2　km,　1　km,　0.5　km,　and　0　km　prior　to　the　beginning　of　the　tapered　deceleration　lane.　If　road　conditions　are　limited,　three　advance　guide　signs　should　be　used.