Noble-metal-free　photocatalysts　have　attracted　tremendous　interest　in　recent　years.　Among　them,　cadmium　sulfide　(CdS)　has　been　considered　as　one　of　the　most　important　photocatalysts　with　potential　applications　in　hydrogen　evolution.　However,　its　efficiency　is　relatively　low　due　to　the　fast　recombination　of　photogenerated　charge　carriers.　In　this　work,　defective　CdS　nanospheres　were　designed.　NiS　quantum　dots　were　introduced　to　facilitate　the　efficient　separation　of　photogenerated　electrons　and　holes.　Without　noble　metals,　the　hydrogen　production　of　CdS　nanospheres　with　NiS　quantum　dots　is　similar　to　24　times　higher　than　that　of　pure　CdS　nanospheres,　demonstrating　the　key　role　of　NiS　quantum　dots　for　highly　efficient　separation　of　the　photogenerated　carriers.　Meanwhile,　the　designed　photocatalysts　have　good　stability.　They　can　maintain　similar　to　90%　of　photocatalytic　activity　during　stability　measurements.　A　potential　photocatalytic　mechanism　was　proposed.