This　study　aims　to　enhance　the　critical　current　density　(J(c))　of　a　YBa2Cu3O7-x(YBCO)　film　by　adding　more　pinning　centers　and　reducing　defects.　Perovskite　nanomaterials　with　positive　and　negative　mismatch　lattices　with　respect　to　YBCO　were　simultaneously　doped　on　a　YBCO　film　using　a　low-fluorine　metal　organic　deposition　technique.　The　co-doping　with　both　positive　and　negative　mismatch　dopant　was　revealed　to　be　effective　at　up　to　10%,　as　compared　with　the　previously　reported　amount　for　single　nanoparticles　(i.e.,　7%).　At　doping　levels　of　8　mol%　Ba2YNbO6(positively　mismatch　perovskite)　and　2　mol%　LaAlO3(negatively　mismatch　perovskite),　the　surface　of　the　film　was　observed　to　be　flat　and　dense　with　an　improved　critical　current　density　and　pinning　force.　The　positive　and　negative　mismatched　lattice　eliminated　the　long-range　strains　and　introduced　crystal　defects;　thus,　the　pinning　centers　became　more　effective.　This　study　describes　a　feasible　approach　regarding　the　positive-negative　mismatch　theory　by　providing　an　optimal　design　for　the　effective　pinning　centers　of　a　YBCO　film.　This　approach　can　open　a　gateway　for　advanced　applications　of　second-generation　high-temperature　coated　conductors　at　the　industrial　level.