Oral　squamous　cell　carcinoma　(OSCC)　represents　more　than　90%　of　all　oral　cancers.　The　etiology　of　the　disease　has　been　linked　to　genetics.　To　determine　OSCC-associated　genes,　researchers　usually　test　if　the　mean　expression　level　of　a　gene　among　OSCC　patients　is　different　from　that　among　non-OSCC　patients.　Recently,　researchers　found　that　genes　having　different　variances　between　two　biological　states　are　also　relevant　to　the　disease　of　interest.　To　the　best　of　our　knowledge,　no　differential　variability　analysis　has　been　conducted　to　investigate　the　genetic　risk　factors　of　OSCC　yet.　In　this　article,　we　identified　genes　differentially　variable　between　the　OSCC　cases　and　controls　by　using　the　Brown-Forsythe　test　(BF　test)　based　on　two　public　available　gene　expression　data　sets　(GSE30784　and　GSE6791)　from　the　Gene　Expression　Omnibus.　By　using　the　discovery　set,　we　identified　2,904　DV　gene　probes,　among　which　456　DV　probes　were　replicated　by　the　validation　set.　Our　results　showed　that　differential　variable　genes　could　provide　additional　information　about　the　mechanisms　of　OSCC.