In　this　study,　the　fouling　behavior　of　PES　ultrafiltration　(UF)　membrane　with　different　DOM　fractions　including　bovine　serum　albumin　(BSA),　sodium　alginate　(SA)　and　humic　acid　(HA)　was　systematically　investigated.　The　result　showed　that　the　fouling　mechanism　of　HA　was　cake　formation　while　that　of　BSA　and　SA　was　caused　by　both　pore　blocking　and　cake　formation　due　to　the　different　particle　size.　Moreover,　membrane　fouling　became　more　severe　with　the　increase　of　feed　concentration　and　TMP　and　it　could　be　accurately　described　by　the　cake-complete　model.　The　pore　blocking　resistance　for　SA　was　larger　than　that　for　BSA,　whereas　the　cake　resistance　followed　the　sequence　SA＞BSA＞HA.　This　observation　offered　insight　into　the　differences　in　fouling　behavior　of　the　various　DOM　components　and　was　further　used　as　guidance　for　practical　application.