Radio　frequency　electromagnetic　radiation　(RF-EMR)　which　is　a　form　of　electromagnetic　radiation　with　a　rate　of　oscillation　in　the　range　of　around　3　kHz　to　300　GHz,　has　aroused　worldwide　attention　in　decades　because　of　the　extensive　use　of　mobile　phones　and　electronic　appliances.　To　investigate　whether　the　1800MHz　RF-EMR　could　induced　oxidation　and　the　function　of　Vitamin　C　and　Vitamin　E　for　cells,　Balb/c-3T3,　Hela,　HepG2　and　Eca-109　cells　were　exposed　to　1800MHz　RF-EMR　for　1h　at　the　pattern　of　5　min　on　and　5　min　off.　The　superoxide　dismutase　(SOD)　activity　and　glutathione　(GSH)　content　were　detected.　The　results　indicated　that　1800MHz　RF-EMR　induced　cells　SOD　activity　compensatory　increasing　and　GSH　content　decreasing.　Vitamin　C　and　Vitamin　E　could　scavenge　the　free　radicals　resulting　in　SOD　activity　decreasing　and　GSH　content　increasing.