In　the　absence　of　urea,　urease　is　demonstrated　to　catalyze　the　hydrolysis　and　polycondensation　of　the　SnCl2　aqueous　system　to　form　crystalline　mesoporous　SnO2　at　room　temperature.　The　resulting　SnO2　has　a　high　specific　surface　area　of　231　similar　to　248　m(2)　g(-1)　with　uniform　pore　size　at　3.3nm,　and　the　porous　structure　show　high　thermal　stability.　Interestingly,　the　urease　is　not　co-precipitated　with　the　tin　oxide　but　is　left　in　solution,　which　indicates　the　high　purity　of　tin　oxide　and　the　possibility　for　urease　recovery.　The　characterization　of　inter-mediates　and　final　products　reveal　the　key　feature　of　strategy　presented　in　this　study　is　the　stabilization　of　an　amorphous　tin　oxide　phase　by　urease　and　its　subsequent　transformation　to　crystalline　tin　oxide;　the　phase　transformation　and　removal　of　water　might　be　the　major　reasons　for　pores　forming　process.　And　the　obtained　tin　oxides　exhibit　not　only　enhanced　electrochemical　performance　in　lithium　ion　battery,　but　also　better　sensitivity　toward　hydrogen.