In　order　to　obtain　a　panorama　of　structural　and　functional　brain　abnormalities　as　well　as　the　association　between　the　anatomic　and　functional　alterations　and　clinical　symptoms　in　patients　with　major　depressive　disorder　(MDD),　integrated　magnetic　resonance　imaging　(MRI)　measures　were　implemented　on　21　MDD　patients　and　21　healthy　controls,　to　facilitate　the　multimodality　of　voxel-based　morphometry　(VBM)　analysis,　resting-state　functional　connectivity　analysis,　and　symptom　rating.　MDD　patients　showed　significantly　decreased　gray　matter　volume　(GMV)　in　the　rostral　part　of　anterior　cingulate　cortex　(rACC),　precuneus,　and　superior　parietal　lobule　in　the　right　hemisphere.　By　using　the　above　morphologic　deficits　areas　as　seed　regions,　functional　connectivity　analysis　revealed　reduced　coupling　in　the　limbic-cortical　and　frontoparietal　networks,　respectively.　Subsequent　correlation　analyses　revealed　that　GMV　in　the　rACC　negatively　correlated　with　the　depressive　symptom　severity　and　anxiety　level.　Our　findings　provide　evidence　supporting　both　morphologic　and　functional　deficits　in　the　limbic-cortical　and　frontal-parietal　areas　in　MDD　patients　which　could　account　for　their　dysfunctions　on　emotional　regulation　and　cognition.　Moreover,　the　neural　changes　found　in　rACC　could　be　possible　state　markers　for　evaluating　effects　of　anti-depressive　treatment　and　anxiety　level.