Renal　sympathetic　denervation　(RSD)　is　a　new　method　for　the　treatment　of　resistant　hypertension　(RH).　However,　few　studies　have　focused　on　the　effects　of　RSD　on　blood　flow　and　the　interaction　between　temperature　field　and　flow　field.　In　this　paper,　firstly,　we　designed　a　numerical　simulation　of　electromagnetic　field,　flow　field　and　temperature　field　coupling　by　finite　element　method.　Secondly,　numerical　simulation　results　were　verified　by　particle　image　velocimetry　(PIV)　and　vitro　experiment.　From　the　simulation　results,　when　the　flow　velocity　increases　to　0.05　m/s,　the　turbulence　near　the　electrode　disappeared　and　flow　state　became　uniform　laminar　flow.　With　the　increases　of　flow　velocity　(0　m/s　to　0.1　m/s),　temperature　rise　of　the　renal　artery,　the　electrode　tip　and　blood　decreased　from　13　degrees　C,　24　degrees　C　and　5.4　degrees　C　to　9.3　degrees　C,　9.7　degrees　C　and　0.2　degrees　C,　respectively.　From　PIV　experiment　and　vitro　experiment　results,　when　the　flow　rate　increases　to　0.5　L/min,　it　appeared　similar　phenomenon　with　the　velocity　of　0.05　m/s　in　simulation.　With　the　increases　of　flow　rate　(0　L/min　to　0.8　L/min),　temperature　rise　of　three　points　decreased　from　11.2　degrees　C,　20.5　degrees　C　and　3.6　degrees　C　to　7.8　degrees　C,　8.5　degrees　C,　and　0.4　degrees　C,　respectively.　When　the　blood　flow　rate　exceeds　0.5　L/min,　there　is　no　large　velocity　gradient　and　reflux　area　in　the　flow　field,　so　there　will　be　no　hemolysis　and　thrombosis.　Therefore,　the　temperature　field　has　less　influence　on　the　flow　field.　With　the　increase　of　flow　rate,　the　temperature　at　all　three　points　decreases.　Therefore,　the　flow　field　has　an　effect　on　the　temperature　field.　But　the　central　temperature　of　renal　artery　can　still　reach　the　treatment　target　in　which　temperature　rises　to　be　more　than　6　degrees　C.　Therefore,　this　study　preliminarily　verified　the　safety　and　effectiveness　of　RSD.