The　strong　interaction　between　Au　nanoparticles　and　support　(Au-metal　oxide　interface)　usually　governs　the　performance　of　a　supported　Au　catalyst　in　heterogeneous　catalysis.　In　this　study,　a　series　of　Au/reduced　graphene　oxide　(rGO)/　three-dimensionally　ordered　macroporous　(3DOM)　Co(3)O(4　)catalysts　with　similar　textural　properties　were　prepared　using　the　poly(methyl　methacrylate)-templating　and　poly(vinyl　alcohol)-protected　reduction　strategies.　It　was　found　that　introducing　reduced　graphene　oxide　(rGO)　as　an　electron-transfer　bridge　between　Au　and　3DOM　Co3O4　could　significantly　strengthen　the　strong　metal-support　interaction　(SMSI),　thus　enhancing　the　catalytic　activity　for　CO　oxidation.　Among　all　of　the　catalysts,　1.86　wt　%　Au/2　wt　%　rGO/3DOM　Co3O4　(1.86Au/2rGO/3DOM　Co3O4)　showed　the　highest　catalytic　activity:　the　CO　reaction　rate　at　40　degrees　C　(432.8　mu　mol/(g(Au)　s))　was　2　times　higher　than　that　(208.2　mu　mol/(g(Au)　s))　over　1.87Au/3DOM　Co3O4　.　The　introduction　of　rGO　could　improve　the　activation　of　oxygen　molecules　and　hence　increase　the　low-temperature　catalytic　activity.　The　strategy　for　strengthening　the　SMSI　via　rGO　mediation　would　guide　the　designing　of　highly　efficient　supported　metal　catalysts　for　low-temperature　oxidation　of　CO.