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作者:

Yun, Ruijuan (Yun, Ruijuan.) | Lin, Chung-Chih (Lin, Chung-Chih.) | Wu, Shuicai (Wu, Shuicai.) (学者:吴水才) | Huang, Chu-Chung (Huang, Chu-Chung.) | Lin, Ching-Po (Lin, Ching-Po.) | Chao, Yi-Ping (Chao, Yi-Ping.)

收录:

CPCI-S

摘要:

In this study, we employed diffusion tensor imaging (DTI) to construct brain structural network and then derive the connection matrices from 96 healthy elderly subjects. The correlation analysis between these topological properties of network based on graph theory and the Cognitive Abilities Screening Instrument (CASI) index were processed to extract the significant network characteristics. These characteristics were then integrated to estimate the models by various machine-learning algorithms to predict user's cognitive performance. From the results, linear regression model and Gaussian processes model showed presented better abilities with lower mean absolute errors of 5.8120 and 6.25 to predict the cognitive performance respectively. Moreover, these extracted topological properties of brain structural network derived from DTI also could be regarded as the bio-signatures for further evaluation of brain degeneration in healthy aged and early diagnosis of mild cognitive impairment (MCI).

关键词:

cognitive abilities screening instrument (CASI) Diffusion tensor imaging (DTI) Gaussian processes model graph theory linear regression model mild cognitive impairment (MCI)

作者机构:

  • [ 1 ] [Lin, Chung-Chih]Chang Gung Univ, Dept Comp Sci & Informat Engn, Taoyuan, Taiwan
  • [ 2 ] [Chao, Yi-Ping]Chang Gung Univ, Dept Comp Sci & Informat Engn, Taoyuan, Taiwan
  • [ 3 ] [Yun, Ruijuan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 4 ] [Wu, Shuicai]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 5 ] [Huang, Chu-Chung]Natl Yang Ming Univ, Inst Radiol Sci, Taipei, Taiwan
  • [ 6 ] [Lin, Ching-Po]Natl Yang Ming Univ, Inst Neurosci, Taipei, Taiwan

通讯作者信息:

  • [Chao, Yi-Ping]Chang Gung Univ, Dept Comp Sci & Informat Engn, Taoyuan, Taiwan

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来源 :

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)

ISSN: 1557-170X

年份: 2013

页码: 527-530

语种: 英文

被引次数:

WoS核心集被引频次: 3

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