BackgroundInfluenza　A　virus　(IAV)　infection　is　a　serious　public　health　problem　not　only　in　South　East　Asia　but　also　in　European　and　African　countries.　Scientists　are　using　network　biology　to　dig　deep　into　the　essential　host　factors　responsible　for　regulation　of　virus　infections.　Researchers　can　explore　the　virus　invasion　into　the　host　cells　by　studying　the　virus-host　relationship　based　on　their　protein-protein　interaction　network.MethodsIn　this　study,　we　present　a　comprehensive　IAV-host　protein-protein　interaction　network　that　is　obtained　based　on　the　literature-curated　protein　interaction　datasets　and　some　important　interaction　databases.　The　network　is　constructed　in　Cytoscape　and　analyzed　with　its　plugins　including　CytoHubba,　CytoCluster,　MCODE,　ClusterViz　and　ClusterOne.　In　addition,　Gene　Ontology　and　KEGG　enrichment　analyses　are　performed　on　the　highly　IAV-associated　human　proteins.　We　also　compare　the　current　results　with　those　from　our　previous　study　on　Hepatitis　C　Virus　(HCV)-host　protein-protein　interaction　network　in　order　to　find　out　valuable　information.ResultsWe　found　out　1027　interactions　among　829　proteins　of　which　14　are　viral　proteins　and　815　belong　to　human　proteins.　The　viral　protein　NS1　has　the　highest　number　of　associations　with　human　proteins　followed　by　NP,　PB2　and　so　on.　Among　human　proteins,　LNX2,　MEOX2,　TFCP2,　PRKRA　and　DVL2　have　the　most　interactions　with　viral　proteins.　Based　on　KEGG　pathway　enrichment　analysis　of　the　highly　IAV-associated　human　proteins,　we　found　out　that　they　are　enriched　in　the　KEGG　pathway　of　basal　cell　carcinoma.　Similarly,　the　result　of　KEGG　analysis　of　the　common　host　factors　involved　in　IAV　and　HCV　infections　shows　that　these　factors　are　enriched　in　the　infection　pathways　of　Hepatitis　B　Virus　(HBV),　Viral　Carcinoma,　measles　and　certain　other　viruses.ConclusionIt　is　concluded　that　the　list　of　proteins　we　identified　might　be　used　as　potential　drug　targets　for　the　drug　design　against　the　infectious　diseases　caused　by　Influenza　A　Virus　and　other　viruses.