In　order　to　investigate　isolation　effectiveness　on　seismic　performance　of　the　continuous　rigid　frame　bridge,　shaking　table　test　with　nine　sub-tables　on　1/10　scaled　reinforced　concrete　rigid　frame　bridge　specimen　was　performed.　The　experimental　results　demonstrate　that　isolation　devices　provide　flexibility　to　transform　natural　period　of　the　scaled　model,　and　additional　it　can　improve　the　ability　of　energy　dissipation　when　lead　is　used.　The　initial　first　frequency　is　8.17Hz　for　plate-type　rubber　bearing　and　9.12Hz　for　leading　rubber　bearing.　The　plate　rubber　bearing　and　lead-rubber　bearing　are　quite　sensitive　to　seismic　wave　frequency.　The　use　of　various　isolation　devices　affects　response　of　the　bridge　model.　The　results　show　that　the　more　difference　in　the　isolation　devices,　the　more　difference　in　response.　Moreover,　isolation　effect　of　lead-rubber　bearing　show　obviously　more　advantage　than　the　one　of　plate-type　rubber　bearing,　especially　in　controlling　responses　of　the　bridge　during　major　earthquakes.