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作者:

Zhang, Jinli (Zhang, Jinli.) | Jiang, Zongli (Jiang, Zongli.) (学者:蒋宗礼) | Hu, Xiaohua (Hu, Xiaohua.) | Song, Bo (Song, Bo.)

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摘要:

Identifying complex human diseases at molecular level is very helpful, especially in diseases diagnosis, therapy, prognosis and monitoring. Accumulating evidences demonstrated that RNAs are playing important roles in identifying various complex human diseases. However, the amount of verified disease-related RNAs is still little while many of their biological experiments are very time-consuming and labor-intensive. Therefore, researchers have instead been seeking to develop effective computational algorithms to predict associations between diseases and RNAs. In this paper, we propose a novel model called Graph Attention Adversarial Network (GAAN) for the potential disease-RNA association prediction. To our best knowledge, we are among the pioneers to integrate successfully both the state-of-the-art graph convolutional networks (GCNs) and attention mechanism in our model for the prediction of disease-RNA associations. Comparing to other disease-RNA association prediction methods, GAAN is novel in conducing the computations from the aspect of global structure of disease-RNA network with graph embedding while integrating features of local neighborhoods with the attention mechanism. Moreover, GAAN uses adversarial regularization to further discover feature representation distribution of the latent nodes in disease-RNA networks. GAAN also benefits from the efficiency of deep model for the computation of big associations networks. To evaluate the performance of GAAN, we conduct experiments on networks of diseases associating with two different RNAs: MicroRNAs (miRNAs) and Long non-coding RNAs (lncRNAs). Comparisons of GAAN with several popular baseline methods on disease-RNA networks show that our novel model outperforms others by a wide margin in predicting potential disease-RNAs associations.

关键词:

Network representation Gaph convolution networks Adversarial regularization Disease-related association

作者机构:

  • [ 1 ] [Zhang, Jinli]Beijing Univ Technol, Fac Informat Technol, Beijing 100124, Peoples R China
  • [ 2 ] [Jiang, Zongli]Beijing Univ Technol, Fac Informat Technol, Beijing 100124, Peoples R China
  • [ 3 ] [Hu, Xiaohua]Drexel Univ, Coll Comp & Informat, Philadelphia, PA 19104 USA
  • [ 4 ] [Song, Bo]Drexel Univ, Coll Comp & Informat, Philadelphia, PA 19104 USA

通讯作者信息:

  • [Zhang, Jinli]Beijing Univ Technol, Fac Informat Technol, Beijing 100124, Peoples R China

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来源 :

METHODS

ISSN: 1046-2023

年份: 2020

卷: 179

页码: 81-88

4 . 8 0 0

JCR@2022

ESI学科: BIOLOGY & BIOCHEMISTRY;

ESI高被引阀值:136

被引次数:

WoS核心集被引频次: 20

SCOPUS被引频次: 23

ESI高被引论文在榜: 0 展开所有

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