The　UF　membrane　with　a　narrow　and　uniform　pore　size　distribution　and　a　low　tendency　to　foul　has　significant　applications　in　wastewater　treatment.　A　major　hindrance　in　the　preparation　of　the　UF　membrane　with　these　features　is　the　lack　of　a　scalable　and　economical　membrane　fabrication　method.　Herein,　we　devise　a　new　strategy　to　prepare　a　high-quality　polyvinylidene　fluoride/polymethyl　acrylate/cellulose　acetate　(PVDF/PMMA/CA)　blend　UF　membrane　via　a　combination　of　the　etching　mechanism　with　the　traditional　Loeb-Sourirajan　(L-S)　phase　inversion　method.　Different　concentrations　of　silicon　dioxide　(SiO2)　nanoparticles　(NP)　in　the　membrane　matrix　were　etched　by　using　a　0.2　M　hydrofluoric　acid　(HF)　solution　in　a　coagulation　bath.　This　strategy　provided　the　membrane　with　unique　features　along　with　a　narrow　and　uniform　pore　size　distribution　(0.030　+/-　0.005　mu　m).　The　etched　membrane　exhibits　an　increase　of　2.3　times　in　pure　water　flux　(PWF)　and　of　6.5　times　in　permeate　flux(PF),　with　a　slight　decrease　in　rejection　ratio　(93.2%　vs.　97%)　when　compared　to　than　that　of　the　un-etched　membrane.　Moreover,　this　membrane　displayed　outstanding　antifouling　ability,　i.e.,　a　flux　recovery　ratio　(FRR)　of　97%　for　1000　mg/L　bovine　serum　albumin　(BSA)　solution,　a　low　irreversible　fouling　ratio　of　0.5%,　and　highly　enhanced　hydrophilicity　due　to　the　formation　of　pores/voids　throughout　the　membrane　structure.　The　aforementioned　features　of　the　etched　membrane　indicate　that　the　proposed　method　of　etching　SiO2NP　in　membrane　matrix　has　a　great　potential　to　improve　the　structure　and　separation　efficiency　of　a　PVDF/PMMA/CA　blend　membrane.