A　12-lead　ECG　data　acquisition　system　based　on　ADS1298　is　presented　in　this　paper.　ADS1298　is　a　latest　16-channel　24-bit　Analog　to　Digital　Converter　(ADC)　made　in　TI　Company,　which　has　the　characters　of　high-precision,　low　power　and　low　noise,　with　the　internal　integration　of　the　input　multiplexers,　analog　low-pass　filter,　and　digital　filter,　etc.　Combined　with　the　high-speed　low-power　chip　M051　as　MCU,　it　can　achieve　the　standard　12-lead　simultaneous　ECG　acquisition.　ECG　data　can　also　be　transmitted　to　an　upper　host　PC　though　nRF24LE1　MCU.　This　system　greatly　compact　the　circuit　and　reduce　the　power　cost,　as　well　as　implement　the　wireless　transmission.　It　has　laid　the　foundation　for　the　future　high-accuracy　portable　ECG　instrument.　(C)　2011　Published　by　Elsevier　Ltd.　Selection　and/or　peer-review　under　responsibility　of　Harbin　University　of　Science　and　Technology