Regional　earthquake　disaster　macro　risk　assessment　model　can　be　devided　into　two　parts:economic　losses　and　casualities.　through　the　compare　of　domestic　earthquake　disaster　as-sessment　model,the　existing　model　evaluation　index　is　sole,and　it　can　not　reflect　the　differences　of　urban　earthquake　disaster　in　the　area,according　to　this　we　built　the　regional　seismic　disaster　evaluation　index　system,　and　use　the　PCA　method　to　analyze　the　index,and　get　the　weights　of　each　index,further　to　build　the　regional　seismic　disaster　economic　loss　evaluation　index　system　effectde　by　multiple　in-dex.Take　the　previous　data　between　1996　to　2009　as　an　example　to　analyze,compare　the　reckoning　and　the　existing　model　evaluate　results,and　check　the　effectiveness　and　feasibility　of　the　model.