In　this　paper,　the　effect　of　laser　parameters　on　fatigue　life　was　investigated　by　laser　irradiation　for　the　undamaged　and　pre-damaged　copper　film　specimens　with　thickness　of　25　mu　m.　The　results　showed　that　the　laser　parameters　have　a　great　impact　on　the　strengthening　of　original　specimens　and　the　healing　of　specimens　with　fatigue　damage,　and　total　fatigue　life　of　the　healed　specimen　with　fatigue　damage　was　longer　than　that　of　the　strengthened　original　specimen.　According　to　the　obtained　fatigue　life　results　under　different　laser　irradiation　conditions,　the　optimal　laser　parameters　were　identified.　The　fracture　morphology　was　observed　by　SEM.　The　results　showed　that,　under　the　optimal　laser　parameters　condition,　a　dense　layer　was　found　on　the　surface　of　specimen　and　the　columnar　gains　were　refined,　which　results　in　increasing　the　total　fatigue　life　of　the　specimen.