SPECT　(single　photon　emission　computed　tomography)　is　a　non-invasive,　cost-effective　means　for　assessment　of　tissue/organ　functions　in　nuclear　medicine.　For　more　accurate　diagnosis,　quantitative　reconstruction　of　radiotracer　concentration　at　any　location　inside　the　body　is　desired.　To　achieve　this　goal,　we　have　to　address　a　number　of　factors　that　significantly　degrade　the　acquired　projection　data.　The　cone-beam　SPECT　system　has　higher　resolution　comparing　with　parallel-beam　and　fan-beam　SPECT,　which　is　highly　advantageous　in　small　object　detection.　In　this　paper,　we　used　four　analytical　reconstruction　schemes　for　cone-beam　SPECT　that　allow　simultaneous　compensation　for　non-uniform　attenuation　and　distance-dependent　resolution　variation　(DDRV),　as　well　as　accurate　treatment　of　Poisson　noise.　The　simulation　results　show　that　the　reconstruction　scheme　1　and　4　both　can　obtain　good　reconstruction　results.