The　CA　hybrid　membrane　with　enhanced　anti-fouling　property　and　higher　permeability　was　prepared　by　nonsolvent　induced　phase　separation　method　combined　with　chemical　reaction.　The　impacts　of　different　solvents　(N-methyl-2-pyrrolidone,　N,　N-　Dimethylacetamide,　Dimethyl　sulfoxide　and　N,　N-Dimethylformamide),　organic　acids　(citric　acid/fumaric　acid)　and　titanium　dioxide　(TiO2)　nanoparticles　(NPs)　on　the　separation　performance　and　thermal　stability　of　CA　hybrid　membranes　were　investigated.　Results　showed　that　the　introduction　of　organic　acids　to　membrane　matrix　caused　asymmetry　in　the　membrane　structure　with　more　uniform　pore　size　distribution　and　higher　porosity　(82.5%).　This　is　attributed　to　the　production　of　CO(2)bubbles　by　a　reaction　between　organic　acid　in　the　casting　solution　and　salt　in　the　coagulation　bath.　Meanwhile,　a　tremendous　rise　in　anti-fouling　property　(from　89.7%　to　94%),　pure　water　flux　(from　329.7　to　821.5　L/m(2)h)　and　permeation　flux　(from　265.8　to　546.3　L/m(2)h)　indicates　a　significant　improvement　in　the　hydrophilicity　and　the　permeability　of　prepared　membranes.　In　addition,　a　significant　improvement　in　thermal　stability　(by　90　degrees　C)　was　achieved　owing　to　the　formation　of　dative　bonds　between　TiO(2)NPs　and　CA　polymer.　Therefore,　this　approach　can　significantly　improve　the　anti-fouling　property　and　the　separation　performance　of　the　CA　membrane.