Human　immunodeficiency　virus　type　I　(HIV-1)　integrase　(IN)　is　an　essential　enzyme　in　the　lifecycle　of　this　virus　and　also　an　important　target　for　the　study　of　anti-HIV　drugs.　In　the　current　work,　a　model　for　the　active　site　of　IN　and　viral　DNA　was　built　by　combining　experimental　data　with　the　results　of　steered　molecular　dynamics　simulation.　The　model　was　then　taken　into　a　series　automatic　molecular　docking　calculations　with　two　groups　of　inhibitors.　According　to　the　results　of　molecular　docking,　the　inhibitors　of　the　second　group　share　a　similar　binding　model　with　those　of　the　first　group,　though　they　have　no　common　scaffold.　The　newly　built　model　of　the　IN-DNA　complex　is　helpful　for　our　subsequent　research　on　the　design　of　IN　inhibitors.