Many　studies　have　already　demonstrated　structural　brain　differences　among　different　patient　populations　using　the　morphometric　analysis　techniques.　Voxel-based　morphometry　(VBM)　and　deformation-based　morphometry　(DBM)　are　the　two　widely　used　methods.　This　paper　mainly　compared　the　difference　of　the　two　methods　and　analyzed　the　reason　why　many　differences　exist　in　the　experimental　results　focused　on　the　same　disease.　The　first-episode　schizophrenia＇s　brain　structures　were　analyzed　using　both　VBM　and　DBM.　The　results　based　on　the　two　methods　exactly　evaluated　our　analysis　and　provided　pathological　evidence　for　the　first-episode　schizophrenia.